Intensive Care in-hospital mortality prediction has various clinical applications. Neural prediction models, especially when capitalising on clinical notes, have been put forward as improvement on currently existing models. However, to be acceptable these models should be performant and transparent. This work studies different attention mechanisms for clinical neural prediction models in terms of their discrimination and calibration. Specifically, we investigate sparse attention as an alternative to dense attention weights in the task of in-hospital mortality prediction from clinical notes. We evaluate the attention mechanisms based on: i) local self-attention over words in a sentence, and ii) global self-attention with a transformer architecture across sentences. We demonstrate that the sparse mechanism approach outperforms the dense one for the local self-attention in terms of predictive performance with a publicly available dataset, and puts higher attention to prespecified relevant directive words. The performance at the sentence level, however, deteriorates as sentences including the influential directive words tend to be dropped all together.

Multilingual Neural Machine Translation (MNMT) models leverage many language pairs during training to improve translation quality for low-resource languages by transferring knowledge from high-resource languages. We study the quality of a domain-adapted MNMT model in the medical domain for English-Romanian with automatic metrics and a human error typology annotation which includes terminology-specific error categories. We compare the out-of-domain MNMT with the in-domain adapted MNMT. The in-domain MNMT model outperforms the out-of-domain MNMT in all measured automatic metrics and produces fewer terminology errors.

Neural models, with their ability to provide novel representations, have shown promising results in prediction tasks in healthcare. However, patient demographics, medical technology, and quality of care change over time. This often leads to drop in the performance of neural models for prospective patients, especially in terms of their calibration. The deep kernel learning (DKL) framework may be robust to such changes as it combines neural models with Gaussian processes, which are aware of prediction uncertainty. Our hypothesis is that out-of-distribution test points will result in probabilities closer to the global mean and hence prevent overconfident predictions. This in turn, we hypothesise, will result in better calibration on prospective data. This paper investigates DKL's behaviour when facing a temporal shift, which was naturally introduced when an information system that feeds a cohort database was changed. We compare DKL's performance to that of a neural baseline based on recurrent neural networks. We show that DKL indeed produced superior calibrated predictions. We also confirm that the DKL's predictions were indeed less sharp. In addition, DKL's discrimination ability was even improved: its AUC was 0.746 (+- 0.014 std), compared to 0.739 (+- 0.028 std) for the baseline. The paper demonstrated the importance of including uncertainty in neural computing, especially for their prospective use.

由于结构化数据通常不足，因此在开发用于临床信息检索和决策支持系统模型时，需要从电子健康记录中的自由文本中提取标签。临床文本中最重要的上下文特性之一是否定，这表明没有发现。我们旨在通过比较荷兰临床注释中的三种否定检测方法来改善标签的大规模提取。我们使用Erasmus医疗中心荷兰临床语料库比较了基于ContextD的基于规则的方法，即使用MEDCAT和（Fineted）基于Roberta的模型的BilstM模型。我们发现，Bilstm和Roberta模型都在F1得分，精度和召回方面始终优于基于规则的模型。此外，我们将每个模型的分类错误系统地分类，这些错误可用于进一步改善特定应用程序的模型性能。在性能方面，将三个模型结合起来并不有益。我们得出的结论是，尤其是基于Bilstm和Roberta的模型在检测临床否定方面非常准确，但是最终，根据手头的用例，这三种方法最终都可以可行。

In the last years, the number of IoT devices deployed has suffered an undoubted explosion, reaching the scale of billions. However, some new cybersecurity issues have appeared together with this development. Some of these issues are the deployment of unauthorized devices, malicious code modification, malware deployment, or vulnerability exploitation. This fact has motivated the requirement for new device identification mechanisms based on behavior monitoring. Besides, these solutions have recently leveraged Machine and Deep Learning techniques due to the advances in this field and the increase in processing capabilities. In contrast, attackers do not stay stalled and have developed adversarial attacks focused on context modification and ML/DL evaluation evasion applied to IoT device identification solutions. This work explores the performance of hardware behavior-based individual device identification, how it is affected by possible context- and ML/DL-focused attacks, and how its resilience can be improved using defense techniques. In this sense, it proposes an LSTM-CNN architecture based on hardware performance behavior for individual device identification. Then, previous techniques have been compared with the proposed architecture using a hardware performance dataset collected from 45 Raspberry Pi devices running identical software. The LSTM-CNN improves previous solutions achieving a +0.96 average F1-Score and 0.8 minimum TPR for all devices. Afterward, context- and ML/DL-focused adversarial attacks were applied against the previous model to test its robustness. A temperature-based context attack was not able to disrupt the identification. However, some ML/DL state-of-the-art evasion attacks were successful. Finally, adversarial training and model distillation defense techniques are selected to improve the model resilience to evasion attacks, without degrading its performance.

Cybercriminals are moving towards zero-day attacks affecting resource-constrained devices such as single-board computers (SBC). Assuming that perfect security is unrealistic, Moving Target Defense (MTD) is a promising approach to mitigate attacks by dynamically altering target attack surfaces. Still, selecting suitable MTD techniques for zero-day attacks is an open challenge. Reinforcement Learning (RL) could be an effective approach to optimize the MTD selection through trial and error, but the literature fails when i) evaluating the performance of RL and MTD solutions in real-world scenarios, ii) studying whether behavioral fingerprinting is suitable for representing SBC's states, and iii) calculating the consumption of resources in SBC. To improve these limitations, the work at hand proposes an online RL-based framework to learn the correct MTD mechanisms mitigating heterogeneous zero-day attacks in SBC. The framework considers behavioral fingerprinting to represent SBCs' states and RL to learn MTD techniques that mitigate each malicious state. It has been deployed on a real IoT crowdsensing scenario with a Raspberry Pi acting as a spectrum sensor. More in detail, the Raspberry Pi has been infected with different samples of command and control malware, rootkits, and ransomware to later select between four existing MTD techniques. A set of experiments demonstrated the suitability of the framework to learn proper MTD techniques mitigating all attacks (except a harmfulness rootkit) while consuming <1 MB of storage and utilizing <55% CPU and <80% RAM.

Uncertainty quantification is crucial to inverse problems, as it could provide decision-makers with valuable information about the inversion results. For example, seismic inversion is a notoriously ill-posed inverse problem due to the band-limited and noisy nature of seismic data. It is therefore of paramount importance to quantify the uncertainties associated to the inversion process to ease the subsequent interpretation and decision making processes. Within this framework of reference, sampling from a target posterior provides a fundamental approach to quantifying the uncertainty in seismic inversion. However, selecting appropriate prior information in a probabilistic inversion is crucial, yet non-trivial, as it influences the ability of a sampling-based inference in providing geological realism in the posterior samples. To overcome such limitations, we present a regularized variational inference framework that performs posterior inference by implicitly regularizing the Kullback-Leibler divergence loss with a CNN-based denoiser by means of the Plug-and-Play methods. We call this new algorithm Plug-and-Play Stein Variational Gradient Descent (PnP-SVGD) and demonstrate its ability in producing high-resolution, trustworthy samples representative of the subsurface structures, which we argue could be used for post-inference tasks such as reservoir modelling and history matching. To validate the proposed method, numerical tests are performed on both synthetic and field post-stack seismic data.

We present a Machine Learning (ML) study case to illustrate the challenges of clinical translation for a real-time AI-empowered echocardiography system with data of ICU patients in LMICs. Such ML case study includes data preparation, curation and labelling from 2D Ultrasound videos of 31 ICU patients in LMICs and model selection, validation and deployment of three thinner neural networks to classify apical four-chamber view. Results of the ML heuristics showed the promising implementation, validation and application of thinner networks to classify 4CV with limited datasets. We conclude this work mentioning the need for (a) datasets to improve diversity of demographics, diseases, and (b) the need of further investigations of thinner models to be run and implemented in low-cost hardware to be clinically translated in the ICU in LMICs. The code and other resources to reproduce this work are available at https://github.com/vital-ultrasound/ai-assisted-echocardiography-for-low-resource-countries.

Customers are rapidly turning to social media for customer support. While brand agents on these platforms are motivated and well-intentioned to help and engage with customers, their efforts are often ignored if their initial response to the customer does not match a specific tone, style, or topic the customer is aiming to receive. The length of a conversation can reflect the effort and quality of the initial response made by a brand toward collaborating and helping consumers, even when the overall sentiment of the conversation might not be very positive. Thus, through this study, we aim to bridge this critical gap in the existing literature by analyzing language's content and stylistic aspects such as expressed empathy, psycho-linguistic features, dialogue tags, and metrics for quantifying personalization of the utterances that can influence the engagement of an interaction. This paper demonstrates that we can predict engagement using initial customer and brand posts.

Objective. The impact of social determinants of health (SDoH) on patients' healthcare quality and the disparity is well-known. Many SDoH items are not coded in structured forms in electronic health records. These items are often captured in free-text clinical notes, but there are limited methods for automatically extracting them. We explore a multi-stage pipeline involving named entity recognition (NER), relation classification (RC), and text classification methods to extract SDoH information from clinical notes automatically. Materials and Methods. The study uses the N2C2 Shared Task data, which was collected from two sources of clinical notes: MIMIC-III and University of Washington Harborview Medical Centers. It contains 4480 social history sections with full annotation for twelve SDoHs. In order to handle the issue of overlapping entities, we developed a novel marker-based NER model. We used it in a multi-stage pipeline to extract SDoH information from clinical notes. Results. Our marker-based system outperformed the state-of-the-art span-based models at handling overlapping entities based on the overall Micro-F1 score performance. It also achieved state-of-the-art performance compared to the shared task methods. Conclusion. The major finding of this study is that the multi-stage pipeline effectively extracts SDoH information from clinical notes. This approach can potentially improve the understanding and tracking of SDoHs in clinical settings. However, error propagation may be an issue, and further research is needed to improve the extraction of entities with complex semantic meanings and low-resource entities using external knowledge.